多发性脑梗死与单发性脑梗死危险因素对比分析_中国循证医学杂志

作者：

赵松耀 ,  刘鸣 , 刘志勤

四川大学华西医院神经内科（成都 610041）;

关键词：

多发性脑梗死单发性脑梗死危险因素

DOI：

10.7507/1672-2531.20080019

视频：

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目的　比较多发性脑梗死（MCI）与单发性脑梗死（SCI）的危险因素，以利于对其进行针对性的防治。
方法　前瞻性连续登记神经内科缺血性脑卒中患者，根据临床和影像学资料分为MCI和SCI组，对可能影响多发性脑梗死发病的24项因素先进行单因素分析，比较可能的危险因素在MCI与SCI组间有无差异，然后进行非条件logistic多元回归分析，校正混杂因素的影响。
结果　年龄、性别、高血压、糖尿病、心瓣膜病、吸烟、脑梗死史、入院首次收缩压等危险因素在MCI与SCI组间有显著差异，logistic多元回归分析显示，年龄[OR=1.014,95% CI 9(1.003,1.026)]、高血压[OR=1.566,95% CI (1.185,2.068)]、吸烟[OR=1.473,95% CI (1.052,2.061)]、脑梗死史[OR=1.948,95% CI (1.326，2.864)]为MCI的独立危险因素。
结论　与SCI相比，年龄、高血压、吸烟、脑梗死史为MCI的独立危险因素。

引用本文： 赵松耀,刘鸣,刘志勤. 多发性脑梗死与单发性脑梗死危险因素对比分析. 中国循证医学杂志, 2008, 08(2): 75-78. doi: 10.7507/1672-2531.20080019 复制

1.	Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2.	Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3.	Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4.	Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5.	[No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6.	周农, 高宗良. 多发性脑梗塞和单发性脑梗塞的对比分析. 安徽医科大学学报, 1990, 25(4): 275-277.
7.	郭宗君, 袁桂芬, 刘学生, 等. 不同病程单发及多发脑梗塞对病人认知障碍的影响. 中国实用内科杂志, 2000, 20(9): 561-562.
8.	汪凯, 卞兴华, 孟玉, 等. 多发梗塞性痴呆与多发性脑梗塞脑容积线性指标的对照研究. 安徽医科大学学报, 2002, 37(6): 451-453.
9.	Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10.	Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11.	李轶男. 高血压病患者并发缺血性脑卒中危险因素分析. 国外医学神经病学神经外科学分册, 1999, 2: 64.
12.	Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13.	Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14.	Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15.	Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

1. Roh JK, Kang DW, Lee SH, et al. Significance of acute multiple brain infarction on diffusion-weighted imaging. Stroke, 2000, 31(3): 688-694.
2. Bernasconi A, Bogousslavsky J, Bassetti C, et al. Multiple acute infarcts in the posterior circulation. J Neurol Neurosurg Psychiatry. 1996, 60(3): 289-296.
3. Bogousslavsky J, Bernasconi A, Kumral E. Acute multiple infarction involving the anterior circulation. Arch Neurol, 1996, 53(1): 50-57.
4. Meng J, Meng C, Yang P, et al. Cognitive impairment in multiple cerebral infarction. Chinese Medical Journal, 1995, 108(4): 315.
5. [No authors listed]. Stroke--1989. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke, 1989, 20(10): 1407-1431.
6. 周农, 高宗良. 多发性脑梗塞和单发性脑梗塞的对比分析. 安徽医科大学学报, 1990, 25(4): 275-277.
7. 郭宗君, 袁桂芬, 刘学生, 等. 不同病程单发及多发脑梗塞对病人认知障碍的影响. 中国实用内科杂志, 2000, 20(9): 561-562.
8. 汪凯, 卞兴华, 孟玉, 等. 多发梗塞性痴呆与多发性脑梗塞脑容积线性指标的对照研究. 安徽医科大学学报, 2002, 37(6): 451-453.
9. Jackson C, Sudlow C. Are lacunar strokes really different? A systematic review of differences in risk factor profiles between lacunar and nonlacunar infarcts. Stroke, 2005, 36(4): 891-901.
10. Arauz A, Murillo L, Cantú C, et al. Prospective study of single and multiple lacunar infarcts using magnetic resonance imaging: risk factors, recurrence, and outcome in 175 consecutive cases. Stroke, 2003, 34(10): 2453-2458.
11. 李轶男. 高血压病患者并发缺血性脑卒中危险因素分析. 国外医学神经病学神经外科学分册, 1999, 2: 64.
12. Vermeer SE, Den Heijer T, Koudstaal PJ, et al. Incidence and risk factors of silent brain infarcts in the population-based Rotterdam Scan Study. Stroke, 2003, 34(2):392-396.
13. Eguchi K, Kabino K, Hoshide S, et al. Smoking is associated with silent cerebrovascular disease in a high-risk Japanese community-dwelling population. Hypertens Res, 2004, 27(10): 747-754.
14. Yamagishi K, Iso H, Kitamura A, et al. Smoking raises the risk of total and ischemic strokes in hypertensive men. Hypertens Res, 2003, 26(3): 209–217.
15. Halperin RO, Michael Gaziano J, Sesso HD, et al. Smoking and the Risk of Incident Hypertension in Middle-aged and Older Men. American Journal of Hypertension, 2008, Epub ahead of print.

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多发性脑梗死与单发性脑梗死危险因素对比分析

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中国循证医学杂志

多发性脑梗死与单发性脑梗死危险因素对比分析

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